Publication: A Structural Model for the Damage-sensing Complex in Bacterial Nucleotide Excision Repair
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Date
2009
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American Society for Biochemistry & Molecular Biology (ASBMB)
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Pakotiprapha, Danaya, Yi Liu, Gregory L. Verdine, and David Jeruzalmi. 2009. “A Structural Model for the Damage-Sensing Complex in Bacterial Nucleotide Excision Repair.” Journal of Biological Chemistry 284 (19) (March 13): 12837–12844. doi:10.1074/jbc.m900571200.
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Abstract
Nucleotide excision repair is distinguished from other DNA repair pathways by its ability to process a wide range of structurally unrelated DNA lesions. In bacteria, damage recognition is achieved by the UvrA·UvrB ensemble. Here, we report the structure of the complex between the interaction domains of UvrA and UvrB. These domains are necessary and sufficient for full-length UvrA and UvrB to associate and thereby form the DNA damage-sensing complex of bacterial nucleotide excision repair. The crystal structure and accompanying biochemical analyses suggest a model for the complete damage-sensing complex.
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