Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression
Date
2012
Author(s)
Liu, Xia
Chan, Chi-Bun
Qi, Qi
Xiao, Ge
He, Xiaolin
Ye, Keqiang
Publisher
American Chemical Society (ACS)
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Citation
Liu, Xia, Chi-Bun Chan, Qi Qi, Ge Xiao, Hongbo R. Luo, Xiaolin He, and Keqiang Ye. 2012. “Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression.” Journal of Medicinal Chemistry 55 (19) (October 11): 8524–8537. doi:10.1021/jm301099x. http://dx.doi.org/10.1021/jm301099x.
Abstract
Structure–activity relationship study shows that the catechol group in 7,8-dihdyroxyflavone, a selective small TrkB receptor agonist, is critical for agonistic activity. To improve the poor pharmacokinetic profiles intrinsic to catechol-containing molecules and to elevate the agonistic effect of the lead compound, we initiated the lead optimization campaign by synthesizing various bioisosteric derivatives. Here we show that the optimized 2-methyl-8-(4'-(pyrrolidin-1-yl)phenyl)chromeno[7,8-d]imidazol-6(1H)-one derivative possesses enhanced TrkB stimulatory activity. Chronic oral administration of this compound significantly reduces the immobility in forced swim test and tail suspension test, two classical antidepressant behavioral animal models, which is accompanied by robust TrkB activation in hippocampus of mouse brain. Further, in vitro ADMET studies demonstrate that this compound possesses the improved features compared to the previous lead compound. Hence, this optimized compound may act as a promising lead candidate for in-depth drug development for treating various neurological disorders including depression.
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