Publication: HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
Open/View Files
Date
2008
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
New England Journal of Medicine (NEJM/MMS)
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Kawai, Tatsuo, A. Benedict Cosimi, Thomas R. Spitzer, Nina Tolkoff-Rubin, Manikkam Suthanthiran, Susan L. Saidman, Juanita Shaffer, et al. 2008. “HLA-Mismatched Renal Transplantation Without Maintenance Immunosuppression.” N Engl J Med 358, no. 4: 353–361. doi:10.1056/nejmoa071074.
Research Data
Abstract
Five patients with end-stage renal disease received combined bone marrow and kidney transplants from HLA single-haplotype mismatched living related donors, with the use of a nonmyeloablative preparative regimen. Transient chimerism and reversible capillary leak syndrome developed in all recipients. Irreversible humoral rejection occurred in one patient. In the other four recipients, it was possible to discontinue all immunosuppressive therapy 9 to 14 months after the transplantation, and renal function has remained stable for 2.0 to 5.3 years since transplantation. The T cells from these four recipients, tested in vitro, showed donor-specific unresponsiveness and in specimens from allograft biopsies, obtained after withdrawal of immunosuppressive therapy, there were high levels of P3 (FOXP3) messenger RNA (mRNA) but not granzyme B mRNA.
Description
Other Available Sources
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service