Publication: A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase
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Date
2016
Published Version
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Taylor & Francis
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Citation
Mullarky, Edouard, Luke L. Lairson, Lewis C. Cantley, and Costas A. Lyssiotis. 2016. “A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.” Molecular & Cellular Oncology 3 (4): e1164280. doi:10.1080/23723556.2016.1164280. http://dx.doi.org/10.1080/23723556.2016.1164280.
Research Data
Abstract
ABSTRACT Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abrogates the proliferation of PHGDH overexpressing breast cancer cells.
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Keywords
3-phosphoglycerate dehydrogenase, cancer metabolism, PHGDH, serine
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