Publication: Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia
Open/View Files
Date
2016
Authors
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Kasar, S., and J. R. Brown. 2016. “Mutational landscape and underlying mutational processes in chronic lymphocytic leukemia.” Molecular & Cellular Oncology 3 (4): e1157667. doi:10.1080/23723556.2016.1157667. http://dx.doi.org/10.1080/23723556.2016.1157667.
Research Data
Abstract
ABSTRACT Sequencing studies have been instrumental in understanding the genetic basis of chronic lymphocytic leukemia (CLL). Our recent whole-genome sequencing study focusing on lower cytogenetic risk CLL demonstrated that CLL mutations can be attributed to 3 key mutational processes—2 types of activation induced-cytidine deaminase (AID) signatures and an aging signature—that operate at different times throughout CLL evolution.
Description
Other Available Sources
Keywords
CLL, mutation signature, somatic hypermutation, Whole genome sequencing
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service