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Geographic Population Structure in Epstein-Barr Virus Revealed by Comparative Genomics

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5203774.pdf (500.02 KB)

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2016

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10.1093/gbe/evw226

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Oxford University Press
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Chiara, M., C. Manzari, C. Lionetti, R. Mechelli, E. Anastasiadou, M. Chiara Buscarinu, G. Ristori, et al. 2016. “Geographic Population Structure in Epstein-Barr Virus Revealed by Comparative Genomics.” Genome Biology and Evolution 8 (11): 3284-3291. doi:10.1093/gbe/evw226. http://dx.doi.org/10.1093/gbe/evw226.

Abstract

Epstein-Barr virus (EBV) latently infects the majority of the human population and is implicated as a causal or contributory factor in numerous diseases. We sequenced 27 complete EBV genomes from a cohort of Multiple Sclerosis (MS) patients and healthy controls from Italy, although no variants showed a statistically significant association with MS. Taking advantage of the availability of ∼130 EBV genomes with known geographical origins, we reveal a striking geographic distribution of EBV sub-populations with distinct allele frequency distributions. We discuss mechanisms that potentially explain these observations, and their implications for understanding the association of EBV with human disease.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203774/pdf/

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comparative genomics, genome sequence, population structure, Epstein-Barr virus

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371005

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