Publication: Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative
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Date
2016
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Oxford University Press
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Citation
Page, K., A. Mirzazadeh, T. M. Rice, J. Grebely, A. Y. Kim, A. L. Cox, M. D. Morris, et al. 2016. “Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.” Open Forum Infectious Diseases 3 (1): ofw024. doi:10.1093/ofid/ofw024. http://dx.doi.org/10.1093/ofid/ofw024.
Abstract
Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.
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acute infection, alanine aminotransferase, hepatitis C virus, IFNL4, jaundice
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