Publication: The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD
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Date
2014
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Suzuki, Naoki, Asif Maroof, Florian T Merkle, Kathryn Koszka, Atsushi Intoh, Ian Armstrong, Rob Moccia, Brandi N Davis-Dusenbery, and Kevin Eggan. 2014. “The mouse C9ORF72 ortholog is enriched in neurons known to degenerate in ALS and FTD.” Nature neuroscience 16 (12): 1725-1727. doi:10.1038/nn.3566. http://dx.doi.org/10.1038/nn.3566.
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Abstract
Using transgenic animals harboring a targeted LacZ insertion, we studied the expression pattern of the C9ORF72 mouse ortholog. Unlike most genes mutated in ALS, which are ubiquitously expressed, the C9ORF72-ortholog was most highly transcribed in the neuronal populations sensitive to degeneration in ALS and FTD. Thus, our study provides a potential explanation for the cell type specificity of neuronal degeneration caused by C9ORF72 mutations.
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Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), C9ORF72, motor neuron, cortical neuron, hippocampus, astrocyte, microglial
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