Publication: Whole genome analysis of a schistosomiasis-transmitting freshwater snail
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Date
2017
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Nature Publishing Group
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Citation
Adema, C. M., L. W. Hillier, C. S. Jones, E. S. Loker, M. Knight, P. Minx, G. Oliveira, et al. 2017. “Whole genome analysis of a schistosomiasis-transmitting freshwater snail.” Nature Communications 8 (1): 15451. doi:10.1038/ncomms15451. http://dx.doi.org/10.1038/ncomms15451.
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Abstract
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
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