Publication: Genomic Analysis of Plasma Cell-Free DNA in Patients With Cancer
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Date
2016
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American Medical Association (AMA)
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Oxnard, Geoffrey R., Cloud P. Paweletz, and Lynette M. Sholl. 2016. “Genomic Analysis of Plasma Cell-Free DNA in Patients With Cancer.” JAMA Oncology (August 18). doi:10.1001/jamaoncol.2016.2835.
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Abstract
The increased importance of cancer genotyping in guiding cancer treatment has created a need for efficient methods for genomic analysis of patients’ cancers. This increased dependence on DNA-based tumor genotyping assays (eg, sequencing, polymerase chain reaction [PCR], fluorescence in situ hybridization [FISH]) has triggered a growing interest in the analysis of free-floating DNA present in the blood of patients with cancer—plasma cell-free DNA (cfDNA). Sensitive PCR techniques together with high-throughput next-generation sequencing (NGS) technologies have evolved to a point where genetic analysis of cfDNA is possible.
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