Publication: Recent advances in understanding the extracellular calcium-sensing receptor
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Date
2016
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F1000Research
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Colella, Matilde, Andrea Gerbino, Aldebaran M. Hofer, and Silvana Curci. 2016. “Recent advances in understanding the extracellular calcium-sensing receptor.” F1000Research 5 (1): F1000 Faculty Rev-2535. doi:10.12688/f1000research.8963.1. http://dx.doi.org/10.12688/f1000research.8963.1.
Abstract
The extracellular calcium-sensing receptor (CaR), a ubiquitous class C G-protein-coupled receptor (GPCR), is responsible for the control of calcium homeostasis in body fluids. It integrates information about external Ca 2+ and a surfeit of other endogenous ligands into multiple intracellular signals, but how is this achieved? This review will focus on some of the exciting concepts in CaR signaling and pharmacology that have emerged in the last few years.
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Keywords
Articles, Cell Signaling, Cell Signaling & Trafficking Structures, Drug Discovery & Design, Endocrine & Metabolic Pharmacology, Membranes & Sorting, Molecular Pharmacology, extracellular Ca2+ sensor, CaR, receptor trafficking
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