Publication: UV signaling pathways within the skin
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Date
2014
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Chen, Hongxiang, Qing Yu Weng, and David E. Fisher. 2014. “UV signaling pathways within the skin.” The Journal of investigative dermatology 134 (8): 2080-2085. doi:10.1038/jid.2014.161. http://dx.doi.org/10.1038/jid.2014.161.
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Abstract
The effects of UVR on the skin include tanning, carcinogenesis, immunomodulation, and synthesis of vitamin D, among others. Melanocortin 1 receptor polymorphisms correlate with skin pigmentation, UV sensitivity, and skin cancer risk. This article reviews pathways through which UVR induces cutaneous stress and the pigmentation response. Modulators of the UV tanning pathway include sunscreen agents, MC1R activators, adenylate cyclase activators, phosphodiesterase 4D3 inhibitors, T oligos, and MITF regulators such as histone deacetylase (HDAC)-inhibitors. UVR, as one of the most ubiquitous carcinogens, represents both a challenge and enormous opportunity in skin cancer prevention.
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Keywords
ultraviolet radiation, melanocyte, melanoma
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