Publication: A genome-wide association study of marginal zone lymphoma shows association to the HLA region
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Date
2015
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Nature Pub. Group
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Vijai, J., Z. Wang, S. I. Berndt, C. F. Skibola, S. L. Slager, S. de Sanjose, M. Melbye, et al. 2015. “A genome-wide association study of marginal zone lymphoma shows association to the HLA region.” Nature Communications 6 (1): 5751. doi:10.1038/ncomms6751. http://dx.doi.org/10.1038/ncomms6751.
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Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10−15) and HLA-B (rs2922994, P=2.43 × 10−9) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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