Publication: Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
Open/View Files
Date
2015
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Gutierrez-Achury, Javier, Alexandra Zhernakova, Sara L. Pulit, Gosia Trynka, Karen A. Hunt, Jihane Romanos, Soumya Raychaudhuri, David A. van Heel, Cisca Wijmenga, and Paul I.W. de Bakker. 2015. “Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.” Nature genetics 47 (6): 577-578. doi:10.1038/ng.3268. http://dx.doi.org/10.1038/ng.3268.
Research Data
Abstract
Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional risk factors independent of the HLA-DQ alleles and observed five novel associations that account for 18% of the genetic risk. Together with the 57 known non-MHC loci, genetic variation can now explain up to 48% of celiac disease heritability.
Description
Other Available Sources
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service