Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy
Open/View files
Date
2015
Author(s)
Mitsuhashi, Kei
Yamamoto, Itaru
Kurihara, Hiroyoshi
Kanno, Shinichi
Ito, Miki
Igarashi, Hisayoshi
Ishigami, Keisuke
Tachibana, Mami
Takahashi, Hiroaki
Tokino, Takashi
Maruyama, Reo
Suzuki, Hiromu
Imai, Kohzoh
Shinomura, Yasuhisa
Yamamoto, Hiroyuki
Nosho, Katsuhiko
Publisher
Impact Journals LLC
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Mitsuhashi, K., I. Yamamoto, H. Kurihara, S. Kanno, M. Ito, H. Igarashi, K. Ishigami, et al. 2015. “Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy.” Oncotarget 6 (26): 22114-22125.
Abstract
Although gastrointestinal carcinoid tumors are relatively rare in the digestive tract, a quarter of them are present in the rectum. In the absence of specific tumor biomarkers, lymphatic or vascular invasion is generally used to predict the risk of lymph node metastasis. We, therefore, examined the genetic and epigenetic alterations potentially associated with lymphovascular invasion among 56 patients with rectal carcinoid tumors. We also conducted a microRNA (miRNA) array analysis. Our analysis failed to detect mutations in BRAF, KRAS, NRAS, or PIK3CA or any microsatellite instability (MSI); however, we did observe CpG island methylator phenotype (CIMP) positivity in 13% (7/56) of the carcinoid tumors. The CIMP-positive status was significantly correlated with lymphovascular invasion (P = 0.036). The array analysis revealed that microRNA-885 (miR-885)-5p was the most up-regulated miRNA in the carcinoid tumors with lymphovascular invasion compared with that in those without invasion. In addition, high miR-885-5p expression was independently associated with lymphovascular invasion (P = 0.0002). In conclusion, our findings suggest that miR-885-5p and CIMP status may be useful biomarkers for predicting biological malignancy in patients with rectal carcinoid tumors.
Other Available Sources
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service
Collection