Publication: Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators
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Date
2015
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Publisher
Taylor & Francis
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Citation
Hatfield, Stephen M., and Michail Sitkovsky. 2015. “Oxygenation to improve cancer vaccines, adoptive cell transfer and blockade of immunological negative regulators.” Oncoimmunology 4 (12): e1052934. doi:10.1080/2162402X.2015.1052934. http://dx.doi.org/10.1080/2162402X.2015.1052934.
Research Data
Abstract
Oxygenation of tumors weakens the tumor-protecting immunosuppressive signaling by A2A adenosine receptors in hypoxic and extracellular adenosine-rich microenvironments. This, in turn, unleashes the otherwise inhibited tumor-reactive T and natural killer (NK) cells. Oxygenation of tumors thus emerges as a novel checkpoint inhibitor of potential therapeutic value, but only in combination with cancer immunotherapies.
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Keywords
Anti-tumor immunity, adenosine receptors, CD8+ T cells, immunotherapies, oxygen, natural killer cells, tumor microenvironment, vaccine
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