Publication: In vitro correlates of HIV-2-mediated HIV-1 protection
Open/View Files
Date
2000
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
Proceedings of the National Academy of Sciences
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Kokkotou, E. G., J.-L. Sankale, I. Mani, A. Gueye-Ndiaye, D. Schwartz, M. E. Essex, S. Mboup, and P. J. Kanki. 2000. In Vitro Correlates of HIV-2-Mediated HIV-1 Protection. Proceedings of the National Academy of Sciences 97 (12) (June 6): 6797–6802. doi:10.1073/pnas.97.12.6797.
Research Data
Abstract
A prospective study of high-risk commercial sex workers in Senegal has shown that HIV-2 infection may reduce the risk of subsequent HIV-1 infection; these findings have been confirmed and extended, now with 13 years of observation. While exploring the biological mechanisms behind this natural protection, we found that a significant proportion of peripheral blood mononuclear cells obtained from HIV-2-infected subjects resisted in vitro challenge with CCR5-dependent HIV-1 viruses but not CXCR4-dependent viruses. High levels of beta-chemokines, the natural ligands of the CCR5 coreceptor, were correlated with low levels of viral replication, and resistance was abrogated by antibodies to beta-chemokines. Our results suggest that beta-chemokine-mediated resistance may be an important correlate of HIV protection against HIV-1 infection and relevant to HIV vaccine design.
Description
Other Available Sources
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service