Monitoring and visualization techniques for MR-guided laser ablations in an open MR system

Abstract

Our purpose was to develop temperature sensitive MR sequences and image-processing techniques to asses their potential of monitoring interstitial laser therapy (ILT) in brain tumors (n = 3) and liver tumors (n = 7). ILT lasted 2 to 26 minutes, while images from T1-weighted Fast-Spin-Echo (FSE)- or Spoiled Gradient-Recalled (SPGR) sequences were acquired within 5 - 13 seconds. Pixel subtraction and visualization of T1-weighted images or optical flow computation was done within less than 110 msec. Alternating, phase-mapping of real- and imaginary components of SPGR sequences was performed within 220 msec. Pixel subtraction of T1-weighted images identified thermal changes in liver and brain tumors but could not evaluate the temperature values as chemical-shift based imaging, which was however, more affected by susceptibility effects and motion. Optical flow computation displayed the predicted course of thermal changes and revealed that the rate of heat deposition can be anisotropic, which may be related to heterogeneous tumor structure and/or vascularization.