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Genetic associations with subjective well-being also implicate depression and neuroticism

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2016

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Nature Publishing Group
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Okbay, Aysu, Bart M.L. Baselmans, Jan-Emmanuel De Neve, et al.. 2016. Genetic associations with subjective well-being also implicate depression and neuroticism. Nature Genetics 48: 624–633

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Abstract

We conducted a genome-wide association study of subjective well-being (SWB) in 298,420 individuals. We also performed auxiliary analyses of depressive symptoms (“DS”; N = 161,460) and neuroticism (N = 170,910), both of which have a substantial genetic correlation with SWB (휌̂≈−0.8). We identify three SNPs associated with SWB at genome-wide significance. Two of them are significantly associated with DS in an independent sample. In our auxiliary analyses, we identify 13 additional genome-wide-significant associations: two with DS and eleven with neuroticism, including two inversion polymorphisms. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are enriched. The discovery of genetic loci associated with the three phenotypes we study has proven elusive; our findings illustrate the payoffs from studying them jointly.

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