Publication: HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults
Open/View Files
Date
2015
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
Oxford University Press
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Matthews, P. C., J. M. Carlson, A. Beloukas, A. Malik, P. Jooste, A. Ogwu, R. Shapiro, et al. 2015. “HLA-A is a Predictor of Hepatitis B e Antigen Status in HIV-Positive African Adults.” The Journal of Infectious Diseases 213 (8): 1248-1252. doi:10.1093/infdis/jiv592. http://dx.doi.org/10.1093/infdis/jiv592.
Research Data
Abstract
Outcomes of chronic infection with hepatitis B virus (HBV) are varied, with increased morbidity reported in the context of human immunodeficiency virus (HIV) coinfection. The factors driving different outcomes are not well understood, but there is increasing interest in an HLA class I effect. We therefore studied the influence of HLA class I on HBV in an African HIV-positive cohort. We demonstrated that virologic markers of HBV disease activity (hepatitis B e antigen status or HBV DNA level) are associated with HLA-A genotype. This finding supports the role of the CD8+ T-cell response in HBV control, and potentially informs future therapeutic T-cell vaccine strategies.
Description
Other Available Sources
Keywords
HBV, HIV, coinfection, immunology, CD8, HLA, HBeAg (hepatitis B e antigen), viral hepatitis, Africa
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service