Publication: Interference between Streptococcus pneumoniae and Staphylococcus aureus: In Vitro Hydrogen Peroxide-Mediated Killing by Streptococcus pneumoniae
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Date
2006
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American Society for Microbiology
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Citation
Regev-Yochay, G., K. Trzcinski, C. M. Thompson, R. Malley, and M. Lipsitch. 2006. “Interference Between Streptococcus Pneumoniae and Staphylococcus Aureus: In Vitro Hydrogen Peroxide-Mediated Killing by Streptococcus Pneumoniae.” Journal of Bacteriology 188 (13) (June 20): 4996–5001. doi:10.1128/jb.00317-06. http://dx.doi.org/10.1128/JB.00317-06.
Research Data
Abstract
The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.
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Keywords
antibiosis*/drug effects, catalase/pharmacology, hydrogen peroxide/pharmacology*, microbial sensitivity tests, pyruvate oxidase/deficiency, pyruvate oxidase/genetics, staphylococcus aureus/drug effects, staphylococcus aureus/physiology*, streptococcus pneumoniae/genetics, streptococcus pneumoniae/growth & development, streptococcus pneumoniae/physiology*
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