Publication: Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
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Date
2015
Published Version
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Publisher
John Wiley and Sons Inc.
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Citation
Celiz, A. D., J. G. W. Smith, A. K. Patel, A. L. Hook, D. Rajamohan, V. T. George, L. Flatt, et al. 2015. “Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.” Advanced Materials (Deerfield Beach, Fla.) 27 (27): 4006-4012. doi:10.1002/adma.201501351. http://dx.doi.org/10.1002/adma.201501351.
Research Data
Abstract
A scalable and cost‐effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off‐the‐shelf after long‐term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC‐derived cells to be realized.
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Keywords
high throughput, human pluripotent stem cells, materials discovery, polymer microarrays, stem cell differentiation
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