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Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration

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2017

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Elsevier
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Choudhuri, Avik, Eva M. Fast, and Leonard I. Zon. 2017. “Using Zebrafish to Study Pathways that Regulate Hematopoietic Stem Cell Self-Renewal and Migration.” Stem Cell Reports 8 (6): 1465-1471. doi:10.1016/j.stemcr.2017.05.018. http://dx.doi.org/10.1016/j.stemcr.2017.05.018.

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Abstract

This perspective describes the usefulness of zebrafish as a model to study interaction of hematopoietic stem cells with the associated niche in vivo, explains how such interactions influence regeneration, migration, and clonality of HSCs, and defines their fate during differentiation.

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HSC, zebrafish, chemical screen, clonality, niche

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