Large CSF Volume Not Attributable to Ventricular Volume in Schizotypal Personality Disorder
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Date
2000
Author(s)
Hirayasu, Yoshio
Fischer, Iris
Fraone, Stephanie
Publisher
American Psychiatric Publishing
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Citation
Dickey, Chandlee C., Martha E. Shenton, Yoshio Hirayasu, Iris Fischer, Martina M. Voglmaier, Margaret A. Niznikiewicz, Larry J. Seidman, Stephanie Fraone, and Robert W. McCarley. 2000. “Large CSF Volume Not Attributable to Ventricular Volume in Schizotypal Personality Disorder.” AJP 157 (1) (January): 48–54. doi:10.1176/ajp.157.1.48.
Abstract
Objective: The purpose of this study was to determine whether schizotypal personality disorder, which has the same genetic diathesis as schizophrenia, manifests abnormalities in whole-brain and CSF volumes. Method: Sixteen right-handed and neuroleptic-naive men with schizotypal personality disorder were recruited from the community and were age-matched to 14 healthy comparison subjects. Magnetic resonance images were obtained from the subjects and automatically parcellated into CSF, gray matter, and white matter. Subsequent manual editing separated cortical from noncortical gray matter. Lateral ventricles and temporal horns were also delineated. Results: The men with schizotypal personality disorder had larger CSF volumes than the comparison subjects; the difference was not attributable to larger lateral ventricles. The cortical gray matter was somewhat smaller in the men with schizotypal personality disorder, but the difference was not statistically significant. Conclusions: Consistent with many studies of schizophrenia, this examination of schizotypal personality disorder indicated abnormalities in brain CSF volumes.
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