Publication: Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform
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Date
2013
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Royal Society of Chemistry (RSC)
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Gianella, Anita, Aneta J. Mieszawska, Freek J. M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, et al. 2013. “Synthesis and in Vitro Evaluation of a Multifunctional and Surface-Switchable Nanoemulsion Platform.” Chemical Communications 49 (82): 9392. doi:10.1039/c3cc43618g.
Abstract
We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using the biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.
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