Publication: Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure
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Date
2017
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Frontiers Media S.A.
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Liu, Tong, Deli Song, Jianzeng Dong, Pinghui Zhu, Jie Liu, Wei Liu, Xiaohai Ma, Lei Zhao, and Shukuan Ling. 2017. “Current Understanding of the Pathophysiology of Myocardial Fibrosis and Its Quantitative Assessment in Heart Failure.” Frontiers in Physiology 8 (1): 238. doi:10.3389/fphys.2017.00238. http://dx.doi.org/10.3389/fphys.2017.00238.
Abstract
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. Myocardial fibrosis results from increased myofibroblast activity and excessive extracellular matrix deposition. Various cells and molecules are involved in this process, providing targets for potential drug therapies. Currently, the main detection methods of myocardial fibrosis rely on serum markers, cardiac magnetic resonance imaging, and endomyocardial biopsy. This review summarizes our current knowledge regarding the pathophysiology, quantitative assessment, and novel therapeutic strategies of myocardial fibrosis.
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Review, mycardial fibrosis, heart failure, late gadolinium enhancement, micro RNAs (miRNAs), biomarkers, extracelluar matrix
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