Publication: Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis
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Date
2017
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MDPI
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Herfs, Michael, Thing R. Soong, Philippe Delvenne, and Christopher P. Crum. 2017. “Deciphering the Multifactorial Susceptibility of Mucosal Junction Cells to HPV Infection and Related Carcinogenesis.” Viruses 9 (4): 85. doi:10.3390/v9040085. http://dx.doi.org/10.3390/v9040085.
Abstract
Human papillomavirus (HPV)-induced neoplasms have long been considered to originate from viral infection of the basal cell layer of the squamous mucosa. However, this paradigm has been recently undermined by accumulating data supporting the critical role of a discrete population of squamo-columnar (SC) junction cells in the pathogenesis of cervical (pre)cancers. The present review summarizes the current knowledge on junctional cells, discusses their high vulnerability to HPV infection, and stresses the potential clinical/translational value of the novel dualistic model of HPV-related carcinogenesis.
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human papillomavirus, squamo-columnar junctions, (pre)neoplastic lesions
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