Publication: Genetic Signatures of Asthma Exacerbation
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Date
2017
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Published Version
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Volume Title
Publisher
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
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Citation
Park, Heung-Woo, and Kelan G. Tantisira. 2017. “Genetic Signatures of Asthma Exacerbation.” Allergy, Asthma & Immunology Research 9 (3): 191-199. doi:10.4168/aair.2017.9.3.191. http://dx.doi.org/10.4168/aair.2017.9.3.191.
Research Data
Abstract
Asthma exacerbation (AE) usually denotes worsening of asthma symptoms that requires intense management to prevent further deterioration. AE has been reported to correlate with clinical and demographic factors, such as race, gender, and treatment compliance as well as environmental factors, such as viral infection, smoking, and air pollution. In addition, recent observations suggest that there are likely to be genetic factors specific to AE. Understanding genetic factors specific to AE is essential to develop therapy tailored for exacerbation-prone asthma. Here, we summarize the results of studies involving genetic risk factors for AE. To simplify and enhance understanding, we reviewed the studies according to the following categories: hypothesis-driven approaches, hypothesis-free approaches, gene-environment interactions, and pharmacogenetics.
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Keywords
Asthma exacerbation, genetics, gene-environment interaction, genome-wide association study, pharmacogenetics
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