Publication: Mechanistic insights into mammalian stress granule dynamics
Open/View Files
Date
2016
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
The Rockefeller University Press
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Panas, Marc D., Pavel Ivanov, and Paul Anderson. 2016. “Mechanistic insights into mammalian stress granule dynamics.” The Journal of Cell Biology 215 (3): 313-323. doi:10.1083/jcb.201609081. http://dx.doi.org/10.1083/jcb.201609081.
Research Data
Abstract
The accumulation of stalled translation preinitiation complexes (PICs) mediates the condensation of stress granules (SGs). Interactions between prion-related domains and intrinsically disordered protein regions found in SG-nucleating proteins promote the condensation of ribonucleoproteins into SGs. We propose that PIC components, especially 40S ribosomes and mRNA, recruit nucleators that trigger SG condensation. With resolution of stress, translation reinitiation reverses this process and SGs disassemble. By cooperatively modulating the assembly and disassembly of SGs, ribonucleoprotein condensation can influence the survival and recovery of cells exposed to unfavorable environmental conditions.
Description
Other Available Sources
Keywords
Review
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service