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Too Little of a Good Thing

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2008

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Ovid Technologies (Wolters Kluwer Health)
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Cohen, Ted, and Marc Lipsitch. 2008. “Too Little of a Good Thing.” Epidemiology 19 (4) (July): 588–589. doi:10.1097/ede.0b013e31817734ba.

Abstract

Epidemic theory dictates that a reduction in the force of infection by a pathogen is associated with an increase in the average age at which individuals are exposed. For those pathogens that cause more severe disease among hosts of an older age, interventions that limit transmission can paradoxically increase the burden of disease in a population.

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age factors, bacterial infections/immunology, disease transmission, infectious/prevention & control, environmental exposure, food microbiology, immunity, immunization, infection control/methods, virulence

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