Publication: Bioinformatics and HIV Latency
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Date
2015
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Publisher
Springer US
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Citation
Ciuffi, Angela, Pejman Mohammadi, Monica Golumbeanu, Julia di Iulio, and Amalio Telenti. 2015. “Bioinformatics and HIV Latency.” Current HIV/AIDS Reports 12 (1): 97-106. doi:10.1007/s11904-014-0240-x. http://dx.doi.org/10.1007/s11904-014-0240-x.
Research Data
Abstract
Despite effective treatment, HIV is not completely eliminated from the infected organism because of the existence of viral reservoirs. A major reservoir consists of infected resting CD4+ T cells, mostly of memory type, that persist over time due to the stable proviral insertion and a long cellular lifespan. Resting cells do not produce viral particles and are protected from viral-induced cytotoxicity or immune killing. However, these latently infected cells can be reactivated by stochastic events or by external stimuli. The present review focuses on novel genome-wide technologies applied to the study of integration, transcriptome, and proteome characteristics and their recent contribution to the understanding of HIV latency.
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Keywords
HIV, Latency, Bioinformatics, Integration, Transcription, Transcriptome, Proteome
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