Publication: Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients
Open/View Files
Date
2015
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Ltd
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Lareau, Caleb A, Indra Adrianto, Albert M Levin, Michael C Iannuzzi, Benjamin A Rybicki, and Courtney G Montgomery. 2015. “Fine mapping of chromosome 15q25 implicates ZNF592 in neurosarcoidosis patients.” Annals of Clinical and Translational Neurology 2 (10): 972-977. doi:10.1002/acn3.229. http://dx.doi.org/10.1002/acn3.229.
Research Data
Abstract
Neurosarcoidosis is a clinical subtype of sarcoidosis characterized by the presence of granulomas in the nervous system. Here, we report a highly significant association with a variant (rs75652600, P = 3.12 × 10−8, odds ratios = 4.34) within a zinc finger gene, ZNF592, from an imputation-based fine-mapping study of the chromosomal region 15q25 in African-Americans with neurosarcoidosis. We validate the association with ZNF592, a gene previously shown to cause cerebellar ataxia, in a cohort of European-Americans with neurosarcoidosis by uncovering low-frequency variants with a similar risk effect size (chr15:85309284, P = 0.0021, odds ratios = 5.36).
Description
Other Available Sources
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service