Publication: Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration
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2013
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Elsevier BV
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Chen, Jing, and Lois E.H. Smith. 2013. Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration. Cell Metabolism 17, no. 4: 471–472. doi:10.1016/j.cmet.2013.03.010.
Abstract
Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of intracellular cholesterol, which promotes neovascular AMD.
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