Attentional Load Effects on Beta Oscillations in Healthy and Schizophrenic Individuals

Abstract

Attentional deficits are prominent among the cognitive disturbances found in schizophrenia. Given that schizophrenia is also characterized by abnormalities in high-frequency oscillations, we investigated whether attentional function in schizophrenia is related to abnormalities in high-frequency oscillations in a visual discrimination task in which attentional load was manipulated. Sixteen healthy control subjects (HC) and 23 chronic schizophrenia patients (SZ) discriminated between target discs (p = 0.2) and standard discs (p = 0.8). Attentional load was manipulated by varying the size difference between the target and standard discs across blocks: large (Easy condition), medium (Medium), and small (Difficult). The electroencephalogram was recorded and the oscillations evoked by the standard stimuli were analyzed using the Morlet wavelet transform. Subjects’ performance decreased as attentional load increased, but HC and SZ did not differ. Attentional load increased β phase-locking factor at frontal, parietal, and occipital electrode sites in HC but not SZ. In SZ, however, there was a correlation between the β attentional load effect and overall d′, indicating that high-performing SZ had relatively normal β attentional load effects. These results show that variations in attentional load are associated with β oscillations and provide a link between attentional dysfunction and β-generating neural circuitry in schizophrenia.