Publication: How drug resistance takes shape
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Date
2016
Published Version
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eLife Sciences Publications, Ltd
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Citation
Jeselsohn, Rinath, and Myles Brown. 2016. “How drug resistance takes shape.” eLife 5 (1): e14973. doi:10.7554/eLife.14973. http://dx.doi.org/10.7554/eLife.14973.
Abstract
Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.
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Keywords
Breast Cancer, Insight, breast cancer, acquired drug resistance, somatic mutation, estrogen receptor alpha, hormone, selective estrogen receptor modulators, Human
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