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Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography

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2016

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Nature Publishing Group
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Song, Jun, Christine Leon Swisher, Hyungsoon Im, Sangmoo Jeong, Divya Pathania, Yoshiko Iwamoto, Misha Pivovarov, Ralph Weissleder, and Hakho Lee. 2016. “Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography.” Scientific Reports 6 (1): 24681. doi:10.1038/srep24681. http://dx.doi.org/10.1038/srep24681.

Abstract

Lens-free digital in-line holography (LDIH) is a promising technology for portable, wide field-of-view imaging. Its resolution, however, is limited by the inherent pixel size of an imaging device. Here we present a new computational approach to achieve sub-pixel resolution for LDIH. The developed method is a sparsity-based reconstruction with the capability to handle the non-linear nature of LDIH. We systematically characterized the algorithm through simulation and LDIH imaging studies. The method achieved the spatial resolution down to one-third of the pixel size, while requiring only single-frame imaging without any hardware modifications. This new approach can be used as a general framework to enhance the resolution in nonlinear holographic systems.

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