Publication: Identification of cell cycle-targeting microRNAs through genome-wide screens
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Date
2017
Published Version
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Publisher
Taylor & Francis
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Citation
Hydbring, Per, Yinan Wang, Roman L. Bogorad, Hao Yin, Daniel G. Anderson, Cheng Li, and Piotr Sicinski. 2017. “Identification of cell cycle-targeting microRNAs through genome-wide screens.” Cell Cycle 16 (23): 2241-2248. doi:10.1080/15384101.2017.1380132. http://dx.doi.org/10.1080/15384101.2017.1380132.
Research Data
Abstract
ABSTRACT By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients.
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Keywords
cyclins, cyclin-dependent kinases, cell cycle, cancer, microRNAs
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