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Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease

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5577383.pdf (1.02 MB)

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2017

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10.1038/ng.3914

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Klarin, D., Q. M. Zhu, C. A. Emdin, M. Chaffin, S. Horner, B. J. McMillan, A. Leed, et al. 2017. “Genetic Analysis in UK Biobank Links Insulin Resistance and Transendothelial Migration Pathways to Coronary Artery Disease.” Nature genetics 49 (9): 1392-1397. doi:10.1038/ng.3914. http://dx.doi.org/10.1038/ng.3914.

Abstract

UK Biobank is among the world’s largest repositories for phenotypic and genotypic information in individuals of European ancestry1. We performed a genome-wide association study in UK Biobank testing ~9 million DNA sequence variants for association with coronary artery disease (4,831 cases; 115,455 controls) and carried out meta-analysis with previously published results. We identified fifteen novel loci, bringing the total number of coronary artery disease-associated loci to 95. Phenome-wide association scanning revealed that CCDC92 likely affects coronary artery disease through insulin resistance pathways whereas experimental analysis suggests that ARHGEF26 impacts the transendothelial migration of leukocytes.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577383/pdf/

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coronary artery disease, population genetics, genome-wide association studies, gene-expression

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868858

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