Publication: Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?
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Date
2018
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SAGE Publications
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Faria-Urbina, Mariana, Rudolf K.F. Oliveira, Sergio A. Segrera, Laurie Lawler, Aaron B. Waxman, and David M. Systrom. 2018. “Impaired systemic oxygen extraction in treated exercise pulmonary hypertension: a new engine in an old car?” Pulmonary Circulation 8 (1): 2045893218755325. doi:10.1177/2045893218755325. http://dx.doi.org/10.1177/2045893218755325.
Abstract
Ambrisentan in 22 patients with pulmonary hypertension diagnosed during exercise (ePH) improved pulmonary hemodynamics; however, there was only a trend toward increased maximum oxygen uptake (VO2max) secondary to decreased maximum exercise systemic oxygen extraction (Ca-vO2). We speculate that improved pulmonary hemodynamics at maximum exercise “unmasked” a pre-existing skeletal muscle abnormality.
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Keywords
systemic oxygen extraction, pulmonary hypertension, ambrisentan, exercise
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