Publication: Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer
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Date
2017
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Public Library of Science
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Citation
En, Junichiro, Sho Kitamoto, Akira Kawashima, Suguru Yonezawa, Yoshito Kishi, Norihisa Ishii, and Masamichi Goto. 2017. “Mycolactone cytotoxicity in Schwann cells could explain nerve damage in Buruli ulcer.” PLoS Neglected Tropical Diseases 11 (8): e0005834. doi:10.1371/journal.pntd.0005834. http://dx.doi.org/10.1371/journal.pntd.0005834.
Research Data
Abstract
Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, fibroblasts and macrophages. Mycolactone induced much higher cell death and apoptosis in Schwann cell line SW10 than in fibroblast line L929. These results suggest that mycolactone is a key substance in the production of nerve damage of Buruli ulcer.
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Keywords
Biology and Life Sciences, Cell Biology, Cellular Types, Animal Cells, Glial Cells, Macroglial Cells, Schwann Cells, Connective Tissue Cells, Fibroblasts, Anatomy, Biological Tissue, Connective Tissue, Medicine and Health Sciences, Cell Processes, Cell Death, Apoptosis, Blood Cells, White Blood Cells, Macrophages, Immune Cells, Immunology, Infectious Diseases, Bacterial Diseases, Buruli Ulcer, Tropical Diseases, Neglected Tropical Diseases, Toxicology, Cytotoxicity, Pathology and Laboratory Medicine, Experimental Organism Systems, Model Organisms, Mouse Models, Animal Models, Epithelial Cells, Endothelial Cells, Epithelium
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