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A Multicenter Blinded Analysis Indicates No Association between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus

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2012

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10.1128/mBio.00266-12

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American Society for Microbiology
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Alter, H. J., J. A. Mikovits, W. M. Switzer, F. W. Ruscetti, S.-C. Lo, N. Klimas, A. L. Komaroff, et al. 2012. “A Multicenter Blinded Analysis Indicates No Association Between Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Either Xenotropic Murine Leukemia Virus-Related Virus or Polytropic Murine Leukemia Virus.” mBio 3 (5) (September 18): e00266–12–e00266–12. doi:10.1128/mbio.00266-12.

Abstract

Thedisablingdisorderknownaschronicfatiguesyndromeormyalgicencephalomyelitis(CFS/ME)hasbeenlinkedin two independent studies to infection with xenotropic murine leukemia virus-related virus (XMRV) and polytropic murine leu- kemia virus (pMLV). Although the associations were not confirmed in subsequent studies by other investigators, patients con- tinue to question the consensus of the scientific community in rejecting the validity of the association. Here we report blinded analysis of peripheral blood from a rigorously characterized, geographically diverse population of 147 patients with CFS/ME and 146 healthy subjects by the investigators describing the original association. This analysis reveals no evidence of either XMRV or pMLV infection.

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:37156516

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