Pregnancy complications in women with rare tumor suppressor syndromes affecting central and peripheral nervous system

Abstract

Neurofibromatosis type 2 (NF2), tuberous sclerosis (TS), and von Hippel-Lindau disease (VHL) are tumor suppressor syndromes characterized by multiple benign tumors of the peripheral and central nervous system.1 These tumors may lead to an enhanced obstetric risk in female patients, but it is currently unknown whether women with NF2, TS, or VHL experience increased rates of adverse pregnancy outcomes. Current data consist primarily of case series, even the largest of which may lack power because of the small sample sizes.