Publication: Strength in numbers: Phosphofructokinase polymerization prevails in the liver
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2017
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The Rockefeller University Press
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Zaganjor, Elma, Jessica B. Spinelli, and Marcia C. Haigis. 2017. “Strength in numbers: Phosphofructokinase polymerization prevails in the liver.” The Journal of Cell Biology 216 (8): 2239-2241. doi:10.1083/jcb.201706005. http://dx.doi.org/10.1083/jcb.201706005.
Abstract
Numerous metabolic enzymes assemble into filamentous structures, which are thought to serve additional regulatory functions. In this issue, Webb et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701084) show that the liver-specific isoform of phosphofructokinase-1 forms filaments in vitro and localizes as puncta in cells along the plasma membrane. This suggests spatial organization of glycolysis in higher organisms.
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