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Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type 1 Carriers

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Primary LRT2012-262363.pdf (452.66 KB)

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2011-11-09

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10.1155/2012/262363

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Hindawi Limited
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Beltran, Brady E., Pilar Quiñones, Domingo Morales, Jose C. Revilla, Jose C. Alva, Jorge Castillo. "Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type 1 Carriers." Leukemia Research and Treatment 2012 (2011): 262363. DOI: 10.1155/2012/262363

Abstract

We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma. Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV-) encoded RNA within the tumor cells indicating a possible interaction between these two viruses. Furthermore, our three EBV-positive cases presented with similar clinical characteristics such as early clinical stage and low-risk indices. To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients. The potential relationship between HTLV-1 and EBV should be further explored.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505915/

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Research Subject Categories::MEDICINE::Morphology, cell biology, pathology::Morphology::Tumour biology, Research Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::Haematology

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https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369228

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