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18F-Deoxyfluorination of Phenols via Ru π-Complexes

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5621004.pdf (1.06 MB)

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2017

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10.1021/acscentsci.7b00195

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American Chemical Society
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Beyzavi, M. Hassan, Debashis Mandal, Martin G. Strebl, Constanze N. Neumann, Erica M. D’Amato, Junting Chen, Jacob M. Hooker, and Tobias Ritter. 2017. “18F-Deoxyfluorination of Phenols via Ru π-Complexes.” ACS Central Science 3 (9): 944-948. doi:10.1021/acscentsci.7b00195. http://dx.doi.org/10.1021/acscentsci.7b00195.

Abstract

The deficiency of robust and practical methods for 18F-radiofluorination is a bottleneck for positron emission tomography (PET) tracer development. Here, we report the first transition-metal-assisted 18F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atmosphere, large substrate scope, and translatability to generate doses appropriate for PET imaging.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5621004/pdf/

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http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492349

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