Publication: Overcoming Challenges in Engineering the Genetic Code
Date
2016
Authors
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier BV
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Lajoie, M.J., D. Söll, and G.M. Church. 2016. “Overcoming Challenges in Engineering the Genetic Code.” Journal of Molecular Biology 428 (5) (February): 1004–1021. doi:10.1016/j.jmb.2015.09.003.
Research Data
Abstract
Withstanding 3.5 billion years of genetic drift, the canonical genetic code remains such a fundamental foundation for the complexity of life that it is highly conserved across all three phylogenetic domains. Genome engineering technologies are now making it possible to rationally change the genetic code, offering resistance to viruses, genetic isolation from horizontal gene transfer, and prevention of environmental escape by genetically modified organisms. We discuss the biochemical, genetic, and technological challenges that must be overcome in order to engineer the genetic code.
Description
Other Available Sources
Keywords
genomically recoded organism (GRO), expanded genetic code, genome engineering
Terms of Use
This article is made available under the terms and conditions applicable to Open Access Policy Articles (OAP), as set forth at Terms of Service