Publication: Unilateral nerve injury down-regulates mRNA for Na+ channel SCN10A bilaterally in rat dorsal root ganglia
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1997
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Elsevier BV
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Oaklander, Anne Louise, and Allan J Belzberg. 1997. “Unilateral Nerve Injury down-Regulates mRNA for Na+ Channel SCN10A Bilaterally in Rat Dorsal Root Ganglia.” Molecular Brain Research 52 (1) (December): 162–165. doi:10.1016/s0169-328x(97)00239-8.
Abstract
Injury makes sensory neurons abnormally excitable and triggers coincident alterations in relative levels of different types of voltage-gated sodium channels that they express. We report that nerve injury depress levels of SCN10A-specific mRNA in contralateral as well as ipsilateral dorsal root ganglia of rats, suggesting a possible peripheral mechanism for the contralateral ‘mirror-image’ hyperalgesia described in nerve-injured humans and experimental animals
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