Dietary Macronutrient Intake and Lower Urinary Tract Symptoms in Women

Abstract

PURPOSE: To examine associations between macronutrient and total energy intakes with lower urinary tract symptoms (LUTS) in women. Methods: Cross-sectional analysis of 2060 women aged 30-79 years in the population-based Boston Area Community Health Survey (2002-2005). Data were collected by validated food frequency questionnaire and in-person interviews. Outcomes for multivariate logistic regression were moderate-to-severe total LUTS, storage, voiding, and postmicturition symptoms. Results: Greater total energy intake was positively associated with LUTS, specifically among women with lower waist circumferences (< 76 cm, p = .005, P(interaction) = .01). Increased saturated fat intake was = associated with postmicturition symptoms (Quintile 5 vs. 1, odds ratio 3.94, 95% confidence interval 1.57-9.89, P(trend) = .04). High protein intake was positively associated with storage symptoms (P(trend) = .03), particularly nocturia. No consistent associations were observed for carbohydrate, monounsaturated, or polyunsaturated fat intakes. ConclUSIONS: Among women with low waist circumferences, high total daily calorie intake was associated with moderate-to-severe LUTS. Although greater saturated fat intake was linked to postmicturition symptoms, the possibility that postmicturition symptoms in women represent more extensive or severe conditions should be explored in future research. These novel results indicate that dietary contributors to LUTS in women are distinct from those in men and may depend on symptom subtype and body size. Ann Epidemiol 2011;21:421-429.