Publication: Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics
Date
2019-11-12
Published Version
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Publisher
Public Library of Science (PLoS)
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Citation
Hicks AL, Kissler SM, Lipsitch M, Grad YH (2019) Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics. PLoS Biol 17(11): e3000547. https://doi.org/10.1371/journal.pbio.3000547
Research Data
Abstract
The sensitivity of genotype-based diagnostics that predict antimicrobial susceptibility is limited by the extent to which they detect genes and alleles that lead to resistance. As novel resistance variants are expected to emerge, such sensitivity is expected to decline unless the new variants are detected and incorporated into the diagnostic. Here, we present a mathematical framework to define how many diagnostic failures may be expected under varying surveillance regimes and thus quantify the surveillance needed to maintain the sensitivity of genotype-based diagnostics.
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Keywords
General Biochemistry, Genetics and Molecular Biology, General Immunology and Microbiology, General Neuroscience, General Agricultural and Biological Sciences
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