Publication: Prostate Cancer Risk and ESR1 TA, ESR2 CA Repeat Polymorphisms
No Thumbnail Available
Open/View Files
Date
2007
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
American Association for Cancer Research
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
McIntyre, M. H., P. W. Kantoff, M. J. Stampfer, L. A. Mucci, D. Parslow, H. Li, J. M. Gaziano, M. Abe, and J. Ma. 2007. “Prostate Cancer Risk and ESR1 TA, ESR2 CA Repeat Polymorphisms.” Cancer Epidemiology Biomarkers & Prevention 16 (11): 2233–36. https://doi.org/10.1158/1055-9965.epi-07-0481.
Research Data
Abstract
Background: Experimental evidence has suggested that estrogen receptor alpha (coded by the gene ESR1) might increase prostate cancer risk, whereas estrogen receptor beta (coded by the gene ESR2) might reduce prostate cancer risk. Methods: We investigated the relationship with prostate cancer risk of both a TA repeat polymorphism in the ESR1 5' region, ESR1 (TA)(n), and with a CA repeat polymorphism in intron 5 of ESR2, ESR2 (CA)(n), in a case-control study (545 cases and 674 controls) nested in the Physicians' Health Study. Results: Prostate cancer risk was highest for carriers of ESR1 (TA)(24) and ESR1 (TA)(25). Replacing one modal ESR1 (TA)(14) allele with one ESR1 (TA)(24) allele yielded an odds ratio of 1.42 (95% confidence interval, 1.00-2.00; P = 0.05). Replacing one ESR1 (TA)(14) allele with one ESR1 (TA)(25) allele yielded an odds ratio of 2.10 (95% confidence interval, 1.15-3.84; P = 0.02). ESR2 (CA), showed no effects on prostate cancer risk. Conclusions: The ESR1 (TA)(n) polymorphism might play a role in prostate cancer risk.
Description
Other Available Sources
Keywords
Terms of Use
Metadata Only